Publications

Peer reviewed journal articles

1. Jensen A, Clarke EJ, Nugent Z, Paice E, Wylie A, Gringel I, Yamamoto K, Rocchigiani G, Peffers AJ, Cooper L and Peffers M. Inflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomics insight. (2024) Equine Vet J
2. Alhashmi M, Gremida AME, Maharana SK, Antonaci M, Kerr A, Fu S, Lunn S, Turner DA, Al-Maslamani NA, Liu K, Meschis MM, Sutherland H, Wilson P, Clegg P, Wheeler GN, van ‘t Hof RJ, Bou-Gharios G and Yamamoto K*. Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation. (2024) Bone Research
3. de Groot R, Folgado PB, Yamamoto K, Martin DR, Koch CD, Debruin D, Blagg S, Minns AF, Bhutada S, Ahnström J, Larkin J, Aspberg A, Önnerfjord P, Apte SS and Santamaria S. Cleavage of cartilage oligomeric matrix protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease. (2024) Matrix Biol  
4. Minns AF, Qi Y, Yamamoto K, Lee K, Ahnström J and Santamaria S. The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity. (2023) J Biol Chem 299(4), 103048. DOI: J Biol Chem 297(5), 101323. DOI: 10.1016/j.jbc.2021.101323

5. Yamamoto K*, Scavenius C, Meschis MM, Gremida AME, Mogensen EH, Thøgersen IB, Bonelli S, Scilabra SD, Jensen A, Santamaria S, Ahnström J, Bou-Gharios G, Enghild JJ and Nagase H.  A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage. (2022) Matrix Biol 112, 190-218. PMID: 36028175
6. Mogensen EH, Poulsen ET, Thøgersen IB, Yamamoto K, Brüel A and Enghild JJ. The low-density lipoprotein receptor-related protein 1 (LRP1) interactome in the human cornea. (2022) Exp Eye Res 219, 109081. DOI: 10.1016/j.exer.2022.109081
7. Santamaria S, Martin DR, Dong X, Yamamoto K, Apte SS and Ahnström J. Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8. (2021) J Biol Chem 297(5), 101323. DOI: 10.1016/j.jbc.2021.101323
8. Harwood SL, Nielsen NS, Diep K, Jensen KT, Nielsen PK, Yamamoto K and Enghild JJ. Developing selective protease inhibitors by engineering the bait region of human α2-macroglobulin. (2021) J Biol Chem 297(1), 100879. DOI: 10.1016/j.jbc.2021.100879
9. Wilkinson DJ, Falconer AMD, Wright HL, Lin H, Yamamoto K, Cheung K, Charlton SH, Arques MC, Janciauskiene S, Rafaie S, Rankin KS, Young DA and Rowan AD. Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. (2021) FEBS J. DOI: 10.1111/febs.16127
10. Mirastschijski U, Lupše B, Maedler K, Sarma B, Radtke A, Belge G, Dorsch M, Wedekind D, McCawley LJ, Boehm G, Zier U, Yamamoto K, Kelm S and Ågren MS. Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin. (2019) Int J Mol Sci 20, 5234. DOI: 10.3390/ijms20205234
11. Scavenius C, Poulsen EC, Thøgersen BI, Roebuck M, Frostick S, Bou-Gharios G, Yamamoto K, Deleuran B, and Enghild JJ. Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and release active heavy chain 2 in synovial fluids from arthritic patients. (2019) J Biol Chem 294(42),15495-15504. DOI: 10.1074/jbc.RA119.008844
12. Santamaria S, Yamamoto K, Teraz-Orosz A, Koch DC, Apte SS, de Groot R, Lane AD and Ahnström J. Exosite in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis. (2019) Sci Rep9, 10914. DOI: 10.1038/s41598-019-47494-w
13. Coveney CR, Collins I, Mc Fie M, Chanalaris A, Yamamoto K and Wann AKT. Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis. (2018) FASEB J 32(12), 6771-6782. DOI: 10.1096/fj.201800334
14. Santamaria S, Fedorov O, McCafferty J, Murphy G, Dudhia J, Nagase H and Yamamoto K*. Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1. (2017) MAbs 9(4), 595-602. DOI: 10.1080/19420862.2017.1304341
15. Yamamoto K*, Santamaria S, Botkjaer K, Dudhia J, Troeberg L, Itoh Y, Murphy G and Nagase H. Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis. (2017) Arthritis Rheumatol 69(6), 1246-1256. *Featured on Arthritis Research UK website as “a new story”. PMID: 28235248
16. Scilabra SD, Yamamoto K, Pigoni M, Sakakmoto K, Sakamoto K, Müller SA, Papadopolou A, Lichtenthaler SF, Murphy G, Troeberg L, Nagase H and Kadomatsu K. Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue. (2016) Matrix Biol 59, 69-79. DOI: 10.1016/j.matbio.2016.07.004
17. Yamamoto K*, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S, Strickland DK, Hirohata S and Nagase H. MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1. (2016) Matrix Biol 56, 57-73. DOI: 10.1016/j.matbio.2016.03.007
18. Ismail HM, Zarebska J, Troeberg L, Tang X, Stott B, Yamamoto K, Nagase H, Fosang A, Vincent TL and Saklatvala J. JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis. (2016) Arthritis Rheumatol 68(5), 1165-1171. DOI: 10.1002/art.39547
19. Santamaria S, Yamamoto K, Botkjaer K, Tape C, Dyson M, McCafferty J, Murphy G and Nagase H. Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2). (2015) Biochem J 471, 391-401. DOI: 10.1042/BJ20150758
20. Ismail HM, Yamamoto K, Vincent TL, Nagase H, Troeberg L and Saklatvala J. Interleukin 1 acts via c-jun N-terminal kinase-2 signalling pathway to induce aggrecan degradation by human chondrocytes. (2015) Arthritis Rheumatol 67(7), 1826-1836. DOI: 10.1002/art.39099
21. Kelwick R, Wagstaff L, Decock J, Roghi C, Cooley LS, Robinson SD, Arnold H, Gavrilović J, Jaworski DM, Yamamoto K, Nagase H, Seubert B, Krüger A and Edwards DR. Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15. (2015) Int J Cancer 136, E14-26. DOI: 10.1002/ijc.29129
22. Yamamoto K*, Owen K, Parker AE, Scilabra SD, Dudhia J, Strickland DK, Troeberg L and Nagase H. Low-density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4: Functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding. (2014) J Biol Chem 289, 6462-6474. DOI: 10.1074/jbc.M113.545376
23. Yamamoto K, Miyazaki K, and Higashi S. Pericellular proteolysis by matrix metalloproteinase-7 is differentially modulated by cholesterol sulfate, sulfatide and cardiolipin. (2014) FEBS J 281, 3346-3356. DOI: 10.1111/febs.12865
24. Manning HB, Nickdel MB, Yamamoto K, Lagarto JL, Kelly DJ, Talbot CB, Kennedy G, Dudhia J, Lever J, Dunsby C, French P and Itoh Y. Detection of cartilage matrix degradation by autofluorescence lifetime. (2013) Matrix Biol32, 32-38. DOI: 10.1016/j.matbio.2012.11.012
25. Scilabra SD, Troeberg L, Yamamoto K, Emonard H, Thøgersen IB, Enghild JJ, Strickland DK, and Nagase H. Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1. (2013) J Biol Chem 288, 332-342. DOI: 10.1074/jbc.M112.393322
26. Yamamoto K, Troeberg L, Scilabra SD, Pelosi M, Murphy CL, Strickland DK and Nagase H. LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage. (2013) FASEB J 27, 511-521. DOI: 10.1096/fj.12-216671
27. Nuti E, Santamaria S, Casalini F, Yamamoto K, Marinelli L, Pietra VL, Novellino E, Orlandini E, Nencetti S, Marini AM, Salerno S, Taliani S, Settimo FD, Nagase H and Rossello A. Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation. (2013) Eur J Med Chem 62, 379-394. DOI: 10.1016/j.ejmech.2012.12.058
28. Yamamoto K, Miyazaki K and Higashi S. Cholesterol sulfate alters substrate preference of matrix metalloproteinase-7 and promotes degradations of pericellular laminin-332 and fibronectin. (2010) J Biol Chem285, 28862-28873. DOI: 10.1074/jbc.M110.136994
29. Higashi S, Oeda M, Yamamoto K and Miyazaki K. Identification of amino acid residues of matrix metalloproteinase-7 essential for binding to cholesterol sulfate. (2008) J Biol Chem 283, 35735-35744. DOI: 10.1074/jbc.M806285200
30. Tsunezumi J, Yamamoto K, Higashi S and Miyazaki K. Matrilysin (matrix metalloproteinase-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surface. (2008) FEBS J275, 4810-4823. DOI: 10.1111/j.1742-4658.2008.06620.x
31. Yamamoto K, Higashi S, Kioi M, Tsunezumi J, Honke K and Miyazaki K. Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion. (2006) J Biol Chem 281, 9170-9180. DOI: 10.1074/jbc.M510377200
32. Ahmed S, Yamamoto K, Sato Y, Ogawa T, Herrmann A, Higashi S and Miyazaki K. Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity. (2003) Biochem Biophys Res Commun 310, 612-618. DOI: 10.1016/j.bbrc.2003.09.058
33. Kioi M, Yamamoto K, Higashi S, Koshikawa N, Fujita K and Miyazaki K. Matrilysin (MMP-7) induces homotypic adhesion of human colon cancer cells and enhances their metastatic potential in nude mouse model. (2003) Oncogene 22, 8662-8670. DOI: 10.1038/sj.onc.1207181     

Journal Articles Under Review

• Saini K, Cho S, Tewari M, Jalil A, Wang M, Kasznel A, Yamamoto K, Chenoweth D and Discher D. Pan-tissue scaling of stiffness versus fibrillar collagen reflects contractility-driven strain that inhibits fibril degradation. Under revision by Nature Materials.
• Ooi K, Kobayashi Y, Yamamoto K, Jensen A, Kanakis I, Yamashita Y, Sakai T, Jarad F, Nakamura H, Kawashiri S and Bou-Gharios G. Targeted inhibition of aggrecanases prevents temporomandibular joint cartilage degradation in the STR/Ort mouse model of spontaneous osteoarthritis. Submitted to Osteoarthritis Cartilage.articles

Review articles

1. Yamamoto K*, Scilabra DS, Bonelli S, Jensen A, Scavenius C, Enghild JJ and Strickland DK. Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1. (2024) J Biol Chem 300(8), 107521 Online ahead of print.
2. Al-Maslamani NA, Oldershaw R, Tew S, Curran J, D’Hooghe P, Horn HF and Yamamoto K.  Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations. (2022). Cells 11, 4011. DOI: 10.3390/cells11244011

3. Yamamoto K, Wilkinson D and Bou-Gharios G.  Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. (2020) Calcif Tissue Int 109(3), 277-290. DOI: 10.1007/s00223-020-00739-7 (Invited). 
4. Yamamoto K, Murphy G and Troeberg L. Extracellular regulation of metalloproteinases. (2015) Matrix Biol 44-46, 255-263. DOI: 10.1016/j.matbio.2015.02.007 (Invited). 
5. Yamamoto K, Higashi S and Miyazaki K. Structure and function of matrilysin. (2003) Nippon Rinsho 61, 123-127 (Invited).  
6. Yamamoto K, Higashi S and Miyazaki K. Roles of matrilysin (MMP-7) on colon cancer metastasis. (2006)Gastrointestinal Research 14, 552-559 (Invited).

Book chapters 

1. Santamaria S and Yamamoto K*. ADAMTS-5. (2023) Handbook of Proteolytic Enzymes, 4e: Metallopeptidases. In press.

2. Yamamoto K, Isohata M and Higashi S. Expression and purification of active monomeric MMP7. (2023) Methods Mol Biol In press
3. Santamaria S and Yamamoto K*. Analysis of Aggrecanase Activity Using Neoepitope Antibodies. (2020) Methods Mol Biol 2043, 125-136. DOI: 10.1007/978-1-4939-9698-8_11
4. Yamamoto K and Higashi S. Immunoprecipitation. (2013) Experimental Protocols for Protein Research. 2^ndEdition. 
5. Yamamoto K and Higashi S. Immunoprecipitation. (2011) Experimental Protocols for Protein Research. 1st Edition. 

Editorials

1. Kwok HF, Yamamoto K, de Groot R, Scilabra SD and Santamaria S. ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era- Volume II. (2023) Front Mol Biosci. 10:1172288. DOI: 10.3389/fmolb.2023.1172288
2. Yamamoto K, de Groot R, Scilabra SD, Kwok HF and Santamaria S. ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era. (2021) Front Mol Biosci. 8:780242. DOI: 10.3389/fmolb.2021.780242